diff --git a/changelog.d/10426.feature b/changelog.d/10426.feature
new file mode 100644
index 0000000000..9cca6dc456
--- /dev/null
+++ b/changelog.d/10426.feature
@@ -0,0 +1 @@
+Email notifications now state whether an invitation is to a room or a space.
diff --git a/synapse/config/emailconfig.py b/synapse/config/emailconfig.py
index bcecbfec03..8d8f166e9b 100644
--- a/synapse/config/emailconfig.py
+++ b/synapse/config/emailconfig.py
@@ -39,12 +39,13 @@ DEFAULT_SUBJECTS = {
     "messages_from_person_and_others": "[%(app)s] You have messages on %(app)s from %(person)s and others...",
     "invite_from_person": "[%(app)s] %(person)s has invited you to chat on %(app)s...",
     "invite_from_person_to_room": "[%(app)s] %(person)s has invited you to join the %(room)s room on %(app)s...",
+    "invite_from_person_to_space": "[%(app)s] %(person)s has invited you to join the %(space)s space on %(app)s...",
     "password_reset": "[%(server_name)s] Password reset",
     "email_validation": "[%(server_name)s] Validate your email",
 }
 
 
-@attr.s
+@attr.s(slots=True, frozen=True)
 class EmailSubjectConfig:
     message_from_person_in_room = attr.ib(type=str)
     message_from_person = attr.ib(type=str)
@@ -54,6 +55,7 @@ class EmailSubjectConfig:
     messages_from_person_and_others = attr.ib(type=str)
     invite_from_person = attr.ib(type=str)
     invite_from_person_to_room = attr.ib(type=str)
+    invite_from_person_to_space = attr.ib(type=str)
     password_reset = attr.ib(type=str)
     email_validation = attr.ib(type=str)
 
diff --git a/synapse/push/mailer.py b/synapse/push/mailer.py
index 7be5fe1e9b..941fb238b7 100644
--- a/synapse/push/mailer.py
+++ b/synapse/push/mailer.py
@@ -19,7 +19,7 @@ from typing import TYPE_CHECKING, Any, Dict, Iterable, List, Optional, TypeVar
 import bleach
 import jinja2
 
-from synapse.api.constants import EventTypes, Membership
+from synapse.api.constants import EventTypes, Membership, RoomTypes
 from synapse.api.errors import StoreError
 from synapse.config.emailconfig import EmailSubjectConfig
 from synapse.events import EventBase
@@ -600,6 +600,22 @@ class Mailer:
                     "app": self.app_name,
                 }
 
+            # If the room is a space, it gets a slightly different topic.
+            create_event_id = room_state_ids.get(("m.room.create", ""))
+            if create_event_id:
+                create_event = await self.store.get_event(
+                    create_event_id, allow_none=True
+                )
+                if (
+                    create_event
+                    and create_event.content.get("room_type") == RoomTypes.SPACE
+                ):
+                    return self.email_subjects.invite_from_person_to_space % {
+                        "person": inviter_name,
+                        "space": room_name,
+                        "app": self.app_name,
+                    }
+
             return self.email_subjects.invite_from_person_to_room % {
                 "person": inviter_name,
                 "room": room_name,